Integrin αDβ2 influences cerebral edema, leukocyte accumulation and neurologic outcomes in experimental severe malaria
Identifieur interne : 000718 ( Main/Exploration ); précédent : 000717; suivant : 000719Integrin αDβ2 influences cerebral edema, leukocyte accumulation and neurologic outcomes in experimental severe malaria
Auteurs : Isaclaudia G. De Azevedo-Quintanilha [Brésil] ; Adriana Vieira-De-Abreu [Brésil] ; André C. Ferreira [Brésil] ; Patricia A. Reis [Brésil] ; Tathiany I. Silva [Brésil] ; Danielle De O. Nascimento [Brésil] ; Robert A. Campbell [États-Unis] ; Vanessa Estato [Brésil] ; Andrew S. Weyrich [États-Unis] ; Patrícia T. Bozza [Brésil] ; Guy A. Zimmerman [États-Unis] ; Hugo C. Castro-Faria-Neto [Brésil]Source :
- PLoS ONE [ 1932-6203 ] ; 2019.
Abstract
Malaria is an infectious disease of major worldwide clinical importance that causes a variety of severe, or complicated, syndromes including cerebral malaria, which is often fatal. Leukocyte integrins are essential for host defense but also mediate physiologic responses of the innate and adaptive immune systems. We previously showed that targeted deletion of the αD subunit (αD-/-) of the αDβ2 integrin, which is expressed on key leukocyte subsets in mice and humans, leads to absent expression of the integrin heterodimer on murine macrophages and reduces mortality in mice infected with
Url:
DOI: 10.1371/journal.pone.0224610
PubMed: 31869339
PubMed Central: 6927624
Affiliations:
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Le document en format XML
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β<sub>2</sub>
influences cerebral edema, leukocyte accumulation and neurologic outcomes in experimental severe malaria</title>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Integrin α<sub>D</sub>
β<sub>2</sub>
influences cerebral edema, leukocyte accumulation and neurologic outcomes in experimental severe malaria</title>
<author><name sortKey="De Azevedo Quintanilha, Isaclaudia G" sort="De Azevedo Quintanilha, Isaclaudia G" uniqKey="De Azevedo Quintanilha I" first="Isaclaudia G." last="De Azevedo-Quintanilha">Isaclaudia G. De Azevedo-Quintanilha</name>
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<country xml:lang="fr">Brésil</country>
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</placeName>
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<author><name sortKey="Vieira De Abreu, Adriana" sort="Vieira De Abreu, Adriana" uniqKey="Vieira De Abreu A" first="Adriana" last="Vieira-De-Abreu">Adriana Vieira-De-Abreu</name>
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<author><name sortKey="Ferreira, Andre C" sort="Ferreira, Andre C" uniqKey="Ferreira A" first="André C." last="Ferreira">André C. Ferreira</name>
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<country xml:lang="fr">Brésil</country>
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<placeName><settlement type="city">Rio de Janeiro</settlement>
<region type="state">État de Rio de Janeiro</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Silva, Tathiany I" sort="Silva, Tathiany I" uniqKey="Silva T" first="Tathiany I." last="Silva">Tathiany I. Silva</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil</addr-line>
</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro</wicri:regionArea>
<placeName><settlement type="city">Rio de Janeiro</settlement>
<region type="state">État de Rio de Janeiro</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Nascimento, Danielle De O" sort="Nascimento, Danielle De O" uniqKey="Nascimento D" first="Danielle De O." last="Nascimento">Danielle De O. Nascimento</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil</addr-line>
</nlm:aff>
<country xml:lang="fr">Brésil</country>
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<region type="state">État de Rio de Janeiro</region>
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<author><name sortKey="Campbell, Robert A" sort="Campbell, Robert A" uniqKey="Campbell R" first="Robert A." last="Campbell">Robert A. Campbell</name>
<affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Internal Medicine and Program in Molecular Medicine, University of Utah, Salt Lake City, Utah, United States of America</addr-line>
</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine and Program in Molecular Medicine, University of Utah, Salt Lake City, Utah</wicri:regionArea>
<placeName><region type="state">Utah</region>
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<author><name sortKey="Estato, Vanessa" sort="Estato, Vanessa" uniqKey="Estato V" first="Vanessa" last="Estato">Vanessa Estato</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil</addr-line>
</nlm:aff>
<country xml:lang="fr">Brésil</country>
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<placeName><settlement type="city">Rio de Janeiro</settlement>
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</placeName>
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<author><name sortKey="Weyrich, Andrew S" sort="Weyrich, Andrew S" uniqKey="Weyrich A" first="Andrew S." last="Weyrich">Andrew S. Weyrich</name>
<affiliation wicri:level="2"><nlm:aff id="aff002"><addr-line>Department of Internal Medicine and Program in Molecular Medicine, University of Utah, Salt Lake City, Utah, United States of America</addr-line>
</nlm:aff>
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<wicri:regionArea>Department of Internal Medicine and Program in Molecular Medicine, University of Utah, Salt Lake City, Utah</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
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<author><name sortKey="Bozza, Patricia T" sort="Bozza, Patricia T" uniqKey="Bozza P" first="Patrícia T." last="Bozza">Patrícia T. Bozza</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil</addr-line>
</nlm:aff>
<country xml:lang="fr">Brésil</country>
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<placeName><settlement type="city">Rio de Janeiro</settlement>
<region type="state">État de Rio de Janeiro</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Zimmerman, Guy A" sort="Zimmerman, Guy A" uniqKey="Zimmerman G" first="Guy A." last="Zimmerman">Guy A. Zimmerman</name>
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</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Department of Internal Medicine and Program in Molecular Medicine, University of Utah, Salt Lake City, Utah</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
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<author><name sortKey="Castro Faria Neto, Hugo C" sort="Castro Faria Neto, Hugo C" uniqKey="Castro Faria Neto H" first="Hugo C." last="Castro-Faria-Neto">Hugo C. Castro-Faria-Neto</name>
<affiliation wicri:level="3"><nlm:aff id="aff001"><addr-line>Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro, Brazil</addr-line>
</nlm:aff>
<country xml:lang="fr">Brésil</country>
<wicri:regionArea>Laboratório de Imunofarmacologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Rio de Janeiro</wicri:regionArea>
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</analytic>
<series><title level="j">PLoS ONE</title>
<idno type="eISSN">1932-6203</idno>
<imprint><date when="2019">2019</date>
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<front><div type="abstract" xml:lang="en"><p>Malaria is an infectious disease of major worldwide clinical importance that causes a variety of severe, or complicated, syndromes including cerebral malaria, which is often fatal. Leukocyte integrins are essential for host defense but also mediate physiologic responses of the innate and adaptive immune systems. We previously showed that targeted deletion of the α<sub>D</sub>
subunit (α<sub>D</sub>
<sup>-/-</sup>
) of the α<sub>D</sub>
β<sub>2</sub>
integrin, which is expressed on key leukocyte subsets in mice and humans, leads to absent expression of the integrin heterodimer on murine macrophages and reduces mortality in mice infected with <italic>Plasmodium berghei</italic>
ANKA (<italic>P</italic>
. <italic>berghei</italic>
ANKA). To further identify mechanisms involved in the protective effect of α<sub>D</sub>
deletion in this model of severe malaria we examined wild type C57BL/6 (WT) and α<sub>D</sub>
<sup>-/-</sup>
mice after <italic>P</italic>
. <italic>berghei</italic>
ANKA infection and found that vessel plugging and leukocyte infiltration were significantly decreased in the brains of α<sub>D</sub>
<sup>-/-</sup>
animals. Intravital microscopy demonstrated decreased rolling and adhesion of leukocytes in cerebral vessels of α<sub>D</sub>
<sup>-/-</sup>
mice. Flow cytometry analysis showed decreased T-lymphocyte accumulation in the brains of infected α<sub>D</sub>
<sup>-/-</sup>
animals. Evans blue dye exclusion assays demonstrated significantly less dye extravasation in the brains of α<sub>D</sub>
<sup>-/-</sup>
mice, indicating preserved blood-brain barrier integrity. WT mice that were salvaged from <italic>P</italic>
. <italic>berghei</italic>
ANKA infection by treatment with chloroquine had impaired aversive memory, which was not observed in α<sub>D</sub>
<sup>-/-</sup>
mice. We conclude that deletion of integrin α<sub>D</sub>
β<sub>2</sub>
alters the natural course of experimental severe malaria, demonstrating previously unrecognized activities of a key leukocyte integrin in immune-inflammatory responses that mediate cerebral involvement.</p>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Phillips, Ma" uniqKey="Phillips M">MA Phillips</name>
</author>
<author><name sortKey="Burrows, Jn" uniqKey="Burrows J">JN Burrows</name>
</author>
<author><name sortKey="Manyando, C" uniqKey="Manyando C">C Manyando</name>
</author>
<author><name sortKey="Van Huijsduijnen, Rh" uniqKey="Van Huijsduijnen R">RH van Huijsduijnen</name>
</author>
<author><name sortKey="Van Voorhis, Wc" uniqKey="Van Voorhis W">WC Van Voorhis</name>
</author>
<author><name sortKey="Wells, Tnc" uniqKey="Wells T">TNC Wells</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="White, Nj" uniqKey="White N">NJ White</name>
</author>
<author><name sortKey="Pukrittayakamee, S" uniqKey="Pukrittayakamee S">S Pukrittayakamee</name>
</author>
<author><name sortKey="Hien, Tt" uniqKey="Hien T">TT Hien</name>
</author>
<author><name sortKey="Faiz, Ma" uniqKey="Faiz M">MA Faiz</name>
</author>
<author><name sortKey="Mokuolu, Oa" uniqKey="Mokuolu O">OA Mokuolu</name>
</author>
<author><name sortKey="Dondorp, Am" uniqKey="Dondorp A">AM Dondorp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Craig, Ag" uniqKey="Craig A">AG Craig</name>
</author>
<author><name sortKey="Khairul, Mf" uniqKey="Khairul M">MF Khairul</name>
</author>
<author><name sortKey="Patil, Pr" uniqKey="Patil P">PR Patil</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Idro, R" uniqKey="Idro R">R Idro</name>
</author>
<author><name sortKey="Kakooza Mwesige, A" uniqKey="Kakooza Mwesige A">A Kakooza-Mwesige</name>
</author>
<author><name sortKey="Asea, B" uniqKey="Asea B">B Asea</name>
</author>
<author><name sortKey="Ssebyala, K" uniqKey="Ssebyala K">K Ssebyala</name>
</author>
<author><name sortKey="Bangirana, P" uniqKey="Bangirana P">P Bangirana</name>
</author>
<author><name sortKey="Opoka, Ro" uniqKey="Opoka R">RO Opoka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ponsford, Mj" uniqKey="Ponsford M">MJ Ponsford</name>
</author>
<author><name sortKey="Medana, Im" uniqKey="Medana I">IM Medana</name>
</author>
<author><name sortKey="Prapansilp, P" uniqKey="Prapansilp P">P Prapansilp</name>
</author>
<author><name sortKey="Hien, Tt" uniqKey="Hien T">TT Hien</name>
</author>
<author><name sortKey="Lee, Sj" uniqKey="Lee S">SJ Lee</name>
</author>
<author><name sortKey="Dondorp, Am" uniqKey="Dondorp A">AM Dondorp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Baruch, Di" uniqKey="Baruch D">DI Baruch</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miller, Lh" uniqKey="Miller L">LH Miller</name>
</author>
<author><name sortKey="Baruch, Di" uniqKey="Baruch D">DI Baruch</name>
</author>
<author><name sortKey="Marsh, K" uniqKey="Marsh K">K Marsh</name>
</author>
<author><name sortKey="Doumbo, Ok" uniqKey="Doumbo O">OK Doumbo</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Mo, M" uniqKey="Mo M">M Mo</name>
</author>
<author><name sortKey="Lee, Hc" uniqKey="Lee H">HC Lee</name>
</author>
<author><name sortKey="Kotaka, M" uniqKey="Kotaka M">M Kotaka</name>
</author>
<author><name sortKey="Niang, M" uniqKey="Niang M">M Niang</name>
</author>
<author><name sortKey="Gao, X" uniqKey="Gao X">X Gao</name>
</author>
<author><name sortKey="Iyer, Jk" uniqKey="Iyer J">JK Iyer</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Faille, D" uniqKey="Faille D">D Faille</name>
</author>
<author><name sortKey="Combes, V" uniqKey="Combes V">V Combes</name>
</author>
<author><name sortKey="Mitchell, Aj" uniqKey="Mitchell A">AJ Mitchell</name>
</author>
<author><name sortKey="Fontaine, A" uniqKey="Fontaine A">A Fontaine</name>
</author>
<author><name sortKey="Juhan Vague, I" uniqKey="Juhan Vague I">I Juhan-Vague</name>
</author>
<author><name sortKey="Alessi, Mc" uniqKey="Alessi M">MC Alessi</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hughes, Kr" uniqKey="Hughes K">KR Hughes</name>
</author>
<author><name sortKey="Biagini, Ga" uniqKey="Biagini G">GA Biagini</name>
</author>
<author><name sortKey="Craig, Ag" uniqKey="Craig A">AG Craig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Janes, Jh" uniqKey="Janes J">JH Janes</name>
</author>
<author><name sortKey="Wang, Cp" uniqKey="Wang C">CP Wang</name>
</author>
<author><name sortKey="Levin Edens, E" uniqKey="Levin Edens E">E Levin-Edens</name>
</author>
<author><name sortKey="Vigan Womas, I" uniqKey="Vigan Womas I">I Vigan-Womas</name>
</author>
<author><name sortKey="Guillotte, M" uniqKey="Guillotte M">M Guillotte</name>
</author>
<author><name sortKey="Melcher, M" uniqKey="Melcher M">M Melcher</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, Y" uniqKey="Wu Y">Y Wu</name>
</author>
<author><name sortKey="Szestak, T" uniqKey="Szestak T">T Szestak</name>
</author>
<author><name sortKey="Stins, M" uniqKey="Stins M">M Stins</name>
</author>
<author><name sortKey="Craig, Ag" uniqKey="Craig A">AG Craig</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Urban, Bc" uniqKey="Urban B">BC Urban</name>
</author>
<author><name sortKey="Roberts, Dj" uniqKey="Roberts D">DJ Roberts</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schofield, L" uniqKey="Schofield L">L Schofield</name>
</author>
<author><name sortKey="Grau, Ge" uniqKey="Grau G">GE Grau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ryg Cornejo, V" uniqKey="Ryg Cornejo V">V Ryg-Cornejo</name>
</author>
<author><name sortKey="Nie, Cq" uniqKey="Nie C">CQ Nie</name>
</author>
<author><name sortKey="Bernard, Nj" uniqKey="Bernard N">NJ Bernard</name>
</author>
<author><name sortKey="Lundie, Rj" uniqKey="Lundie R">RJ Lundie</name>
</author>
<author><name sortKey="Evans, Kj" uniqKey="Evans K">KJ Evans</name>
</author>
<author><name sortKey="Crabb, Bs" uniqKey="Crabb B">BS Crabb</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Faille, D" uniqKey="Faille D">D Faille</name>
</author>
<author><name sortKey="El Assaad, F" uniqKey="El Assaad F">F El-Assaad</name>
</author>
<author><name sortKey="Alessi, Mc" uniqKey="Alessi M">MC Alessi</name>
</author>
<author><name sortKey="Fusai, T" uniqKey="Fusai T">T Fusai</name>
</author>
<author><name sortKey="Combes, V" uniqKey="Combes V">V Combes</name>
</author>
<author><name sortKey="Grau, Ge" uniqKey="Grau G">GE Grau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Combes, V" uniqKey="Combes V">V Combes</name>
</author>
<author><name sortKey="Coltel, N" uniqKey="Coltel N">N Coltel</name>
</author>
<author><name sortKey="Faille, D" uniqKey="Faille D">D Faille</name>
</author>
<author><name sortKey="Wassmer, Sc" uniqKey="Wassmer S">SC Wassmer</name>
</author>
<author><name sortKey="Grau, Ge" uniqKey="Grau G">GE Grau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Gramaglia, I" uniqKey="Gramaglia I">I Gramaglia</name>
</author>
<author><name sortKey="Velez, J" uniqKey="Velez J">J Velez</name>
</author>
<author><name sortKey="Combes, V" uniqKey="Combes V">V Combes</name>
</author>
<author><name sortKey="Grau, Ge" uniqKey="Grau G">GE Grau</name>
</author>
<author><name sortKey="Wree, M" uniqKey="Wree M">M Wree</name>
</author>
<author><name sortKey="Van Der Heyde, Hc" uniqKey="Van Der Heyde H">HC van der Heyde</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Apinjoh, To" uniqKey="Apinjoh T">TO Apinjoh</name>
</author>
<author><name sortKey="Anchang Kimbi, Jk" uniqKey="Anchang Kimbi J">JK Anchang-Kimbi</name>
</author>
<author><name sortKey="Njua Yafi, C" uniqKey="Njua Yafi C">C Njua-Yafi</name>
</author>
<author><name sortKey="Mugri, Rn" uniqKey="Mugri R">RN Mugri</name>
</author>
<author><name sortKey="Ngwai, An" uniqKey="Ngwai A">AN Ngwai</name>
</author>
<author><name sortKey="Rockett, Ka" uniqKey="Rockett K">KA Rockett</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hansen, Ds" uniqKey="Hansen D">DS Hansen</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hunt, Nh" uniqKey="Hunt N">NH Hunt</name>
</author>
<author><name sortKey="Ball, Hj" uniqKey="Ball H">HJ Ball</name>
</author>
<author><name sortKey="Hansen, Am" uniqKey="Hansen A">AM Hansen</name>
</author>
<author><name sortKey="Khaw, Lt" uniqKey="Khaw L">LT Khaw</name>
</author>
<author><name sortKey="Guo, J" uniqKey="Guo J">J Guo</name>
</author>
<author><name sortKey="Bakmiwewa, S" uniqKey="Bakmiwewa S">S Bakmiwewa</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Souza, Mc" uniqKey="Souza M">MC Souza</name>
</author>
<author><name sortKey="Padua, Ta" uniqKey="Padua T">TA Padua</name>
</author>
<author><name sortKey="Henriques, Mg" uniqKey="Henriques M">MG Henriques</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sahu, U" uniqKey="Sahu U">U Sahu</name>
</author>
<author><name sortKey="Sahoo, Pk" uniqKey="Sahoo P">PK Sahoo</name>
</author>
<author><name sortKey="Kar, Sk" uniqKey="Kar S">SK Kar</name>
</author>
<author><name sortKey="Mohapatra, Bn" uniqKey="Mohapatra B">BN Mohapatra</name>
</author>
<author><name sortKey="Ranjit, M" uniqKey="Ranjit M">M Ranjit</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harris, Es" uniqKey="Harris E">ES Harris</name>
</author>
<author><name sortKey="Mcintyre, Tm" uniqKey="Mcintyre T">TM McIntyre</name>
</author>
<author><name sortKey="Prescott, Sm" uniqKey="Prescott S">SM Prescott</name>
</author>
<author><name sortKey="Zimmerman, Ga" uniqKey="Zimmerman G">GA Zimmerman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ockenhouse, Cf" uniqKey="Ockenhouse C">CF Ockenhouse</name>
</author>
<author><name sortKey="Tegoshi, T" uniqKey="Tegoshi T">T Tegoshi</name>
</author>
<author><name sortKey="Maeno, Y" uniqKey="Maeno Y">Y Maeno</name>
</author>
<author><name sortKey="Benjamin, C" uniqKey="Benjamin C">C Benjamin</name>
</author>
<author><name sortKey="Ho, M" uniqKey="Ho M">M Ho</name>
</author>
<author><name sortKey="Kan, Ke" uniqKey="Kan K">KE Kan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Berendt, Ar" uniqKey="Berendt A">AR Berendt</name>
</author>
<author><name sortKey="Tumer, Gd" uniqKey="Tumer G">GD Tumer</name>
</author>
<author><name sortKey="Newbold, Ci" uniqKey="Newbold C">CI Newbold</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reis, Pa" uniqKey="Reis P">PA Reis</name>
</author>
<author><name sortKey="Estato, V" uniqKey="Estato V">V Estato</name>
</author>
<author><name sortKey="Da Silva, Ti" uniqKey="Da Silva T">TI da Silva</name>
</author>
<author><name sortKey="D Vila, Jc" uniqKey="D Vila J">JC d’Avila</name>
</author>
<author><name sortKey="Siqueira, Ld" uniqKey="Siqueira L">LD Siqueira</name>
</author>
<author><name sortKey="Assis, Ef" uniqKey="Assis E">EF Assis</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bao, Lq" uniqKey="Bao L">LQ Bao</name>
</author>
<author><name sortKey="Nhi, Dm" uniqKey="Nhi D">DM Nhi</name>
</author>
<author><name sortKey="Huy, Nt" uniqKey="Huy N">NT Huy</name>
</author>
<author><name sortKey="Kikuchi, M" uniqKey="Kikuchi M">M Kikuchi</name>
</author>
<author><name sortKey="Yanagi, T" uniqKey="Yanagi T">T Yanagi</name>
</author>
<author><name sortKey="Hamano, S" uniqKey="Hamano S">S Hamano</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pichyangkul, S" uniqKey="Pichyangkul S">S Pichyangkul</name>
</author>
<author><name sortKey="Saengkrai, P" uniqKey="Saengkrai P">P Saengkrai</name>
</author>
<author><name sortKey="Yongvanitchit, K" uniqKey="Yongvanitchit K">K Yongvanitchit</name>
</author>
<author><name sortKey="Heppner, Dg" uniqKey="Heppner D">DG Heppner</name>
</author>
<author><name sortKey="Kyle, De" uniqKey="Kyle D">DE Kyle</name>
</author>
<author><name sortKey="Webster, Hk" uniqKey="Webster H">HK Webster</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Barczyk, M" uniqKey="Barczyk M">M Barczyk</name>
</author>
<author><name sortKey="Carracedo, S" uniqKey="Carracedo S">S Carracedo</name>
</author>
<author><name sortKey="Gullberg, D" uniqKey="Gullberg D">D Gullberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lowell, Ca" uniqKey="Lowell C">CA Lowell</name>
</author>
<author><name sortKey="Mayadas, Tn" uniqKey="Mayadas T">TN Mayadas</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hynes, Ro" uniqKey="Hynes R">RO Hynes</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Harris, Es" uniqKey="Harris E">ES Harris</name>
</author>
<author><name sortKey="Weyrich, As" uniqKey="Weyrich A">AS Weyrich</name>
</author>
<author><name sortKey="Zimmerman, Ga" uniqKey="Zimmerman G">GA Zimmerman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Danilenko, Dm" uniqKey="Danilenko D">DM Danilenko</name>
</author>
<author><name sortKey="Rossitto, Pv" uniqKey="Rossitto P">PV Rossitto</name>
</author>
<author><name sortKey="Van Der Vieren, M" uniqKey="Van Der Vieren M">M Van der Vieren</name>
</author>
<author><name sortKey="Le Trong, H" uniqKey="Le Trong H">H Le Trong</name>
</author>
<author><name sortKey="Mcdonough, Sp" uniqKey="Mcdonough S">SP McDonough</name>
</author>
<author><name sortKey="Affolter, Vk" uniqKey="Affolter V">VK Affolter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="El Gabalawy, H" uniqKey="El Gabalawy H">H el-Gabalawy</name>
</author>
<author><name sortKey="Canvin, J" uniqKey="Canvin J">J Canvin</name>
</author>
<author><name sortKey="Ma, Gm" uniqKey="Ma G">GM Ma</name>
</author>
<author><name sortKey="Van Der Vieren, M" uniqKey="Van Der Vieren M">M Van der Vieren</name>
</author>
<author><name sortKey="Hoffman, P" uniqKey="Hoffman P">P Hoffman</name>
</author>
<author><name sortKey="Gallatin, M" uniqKey="Gallatin M">M Gallatin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miyazaki, Y" uniqKey="Miyazaki Y">Y Miyazaki</name>
</author>
<author><name sortKey="Vieira De Abreu, A" uniqKey="Vieira De Abreu A">A Vieira-de-Abreu</name>
</author>
<author><name sortKey="Harris, Es" uniqKey="Harris E">ES Harris</name>
</author>
<author><name sortKey="Shah, Am" uniqKey="Shah A">AM Shah</name>
</author>
<author><name sortKey="Weyrich, As" uniqKey="Weyrich A">AS Weyrich</name>
</author>
<author><name sortKey="Castro Faria Neto, Hc" uniqKey="Castro Faria Neto H">HC Castro-Faria-Neto</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Miyazaki, Y" uniqKey="Miyazaki Y">Y Miyazaki</name>
</author>
<author><name sortKey="Bunting, M" uniqKey="Bunting M">M Bunting</name>
</author>
<author><name sortKey="Stafforini, Dm" uniqKey="Stafforini D">DM Stafforini</name>
</author>
<author><name sortKey="Harris, Es" uniqKey="Harris E">ES Harris</name>
</author>
<author><name sortKey="Mcintyre, Tm" uniqKey="Mcintyre T">TM McIntyre</name>
</author>
<author><name sortKey="Prescott, Sm" uniqKey="Prescott S">SM Prescott</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Azevedo Quintanilha, Ig" uniqKey="De Azevedo Quintanilha I">IG de Azevedo-Quintanilha</name>
</author>
<author><name sortKey="Vieira De Abreu, A" uniqKey="Vieira De Abreu A">A Vieira-de-Abreu</name>
</author>
<author><name sortKey="Ferreira, Ac" uniqKey="Ferreira A">AC Ferreira</name>
</author>
<author><name sortKey="Nascimento, Do" uniqKey="Nascimento D">DO Nascimento</name>
</author>
<author><name sortKey="Siqueira, Am" uniqKey="Siqueira A">AM Siqueira</name>
</author>
<author><name sortKey="Campbell, Ra" uniqKey="Campbell R">RA Campbell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Aziz, Mh" uniqKey="Aziz M">MH Aziz</name>
</author>
<author><name sortKey="Cui, K" uniqKey="Cui K">K Cui</name>
</author>
<author><name sortKey="Das, M" uniqKey="Das M">M Das</name>
</author>
<author><name sortKey="Brown, Ke" uniqKey="Brown K">KE Brown</name>
</author>
<author><name sortKey="Ardell, Cl" uniqKey="Ardell C">CL Ardell</name>
</author>
<author><name sortKey="Febbraio, M" uniqKey="Febbraio M">M Febbraio</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Weaver, Lc" uniqKey="Weaver L">LC Weaver</name>
</author>
<author><name sortKey="Bao, F" uniqKey="Bao F">F Bao</name>
</author>
<author><name sortKey="Dekaban, Ga" uniqKey="Dekaban G">GA Dekaban</name>
</author>
<author><name sortKey="Hryciw, T" uniqKey="Hryciw T">T Hryciw</name>
</author>
<author><name sortKey="Shultz, Sr" uniqKey="Shultz S">SR Shultz</name>
</author>
<author><name sortKey="Cain, Dp" uniqKey="Cain D">DP Cain</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Geremia, Nm" uniqKey="Geremia N">NM Geremia</name>
</author>
<author><name sortKey="Bao, F" uniqKey="Bao F">F Bao</name>
</author>
<author><name sortKey="Rosenzweig, Te" uniqKey="Rosenzweig T">TE Rosenzweig</name>
</author>
<author><name sortKey="Hryciw, T" uniqKey="Hryciw T">T Hryciw</name>
</author>
<author><name sortKey="Weaver, L" uniqKey="Weaver L">L Weaver</name>
</author>
<author><name sortKey="Dekaban, Ga" uniqKey="Dekaban G">GA Dekaban</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bao, F" uniqKey="Bao F">F Bao</name>
</author>
<author><name sortKey="Dekaban, Ga" uniqKey="Dekaban G">GA Dekaban</name>
</author>
<author><name sortKey="Weaver, Lc" uniqKey="Weaver L">LC Weaver</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Den Steen, Pe" uniqKey="Van Den Steen P">PE Van den Steen</name>
</author>
<author><name sortKey="Deroost, K" uniqKey="Deroost K">K Deroost</name>
</author>
<author><name sortKey="Deckers, J" uniqKey="Deckers J">J Deckers</name>
</author>
<author><name sortKey="Van Herck, E" uniqKey="Van Herck E">E Van Herck</name>
</author>
<author><name sortKey="Struyf, S" uniqKey="Struyf S">S Struyf</name>
</author>
<author><name sortKey="Opdenakker, G" uniqKey="Opdenakker G">G Opdenakker</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Thumwood, Cm" uniqKey="Thumwood C">CM Thumwood</name>
</author>
<author><name sortKey="Hunt, Nh" uniqKey="Hunt N">NH Hunt</name>
</author>
<author><name sortKey="Clark, Ia" uniqKey="Clark I">IA Clark</name>
</author>
<author><name sortKey="Cowden, Wb" uniqKey="Cowden W">WB Cowden</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Beeton, C" uniqKey="Beeton C">C Beeton</name>
</author>
<author><name sortKey="Chandy, Kg" uniqKey="Chandy K">KG Chandy</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Irani, Dn" uniqKey="Irani D">DN Irani</name>
</author>
<author><name sortKey="Griffin, De" uniqKey="Griffin D">DE Griffin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Araujo, Cv" uniqKey="Araujo C">CV Araujo</name>
</author>
<author><name sortKey="Campbell, C" uniqKey="Campbell C">C Campbell</name>
</author>
<author><name sortKey="Goncalves De Albuquerque, Cf" uniqKey="Goncalves De Albuquerque C">CF Goncalves-de-Albuquerque</name>
</author>
<author><name sortKey="Molinaro, R" uniqKey="Molinaro R">R Molinaro</name>
</author>
<author><name sortKey="Cody, Mj" uniqKey="Cody M">MJ Cody</name>
</author>
<author><name sortKey="Yost, Cc" uniqKey="Yost C">CC Yost</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Reis, Pa" uniqKey="Reis P">PA Reis</name>
</author>
<author><name sortKey="Comim, Cm" uniqKey="Comim C">CM Comim</name>
</author>
<author><name sortKey="Hermani, F" uniqKey="Hermani F">F Hermani</name>
</author>
<author><name sortKey="Silva, B" uniqKey="Silva B">B Silva</name>
</author>
<author><name sortKey="Barichello, T" uniqKey="Barichello T">T Barichello</name>
</author>
<author><name sortKey="Portella, Ac" uniqKey="Portella A">AC Portella</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Lackner, P" uniqKey="Lackner P">P Lackner</name>
</author>
<author><name sortKey="Beer, R" uniqKey="Beer R">R Beer</name>
</author>
<author><name sortKey="Heussler, V" uniqKey="Heussler V">V Heussler</name>
</author>
<author><name sortKey="Goebel, G" uniqKey="Goebel G">G Goebel</name>
</author>
<author><name sortKey="Rudzki, D" uniqKey="Rudzki D">D Rudzki</name>
</author>
<author><name sortKey="Helbok, R" uniqKey="Helbok R">R Helbok</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Irwin, S" uniqKey="Irwin S">S Irwin</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Franke Fayard, B" uniqKey="Franke Fayard B">B Franke-Fayard</name>
</author>
<author><name sortKey="Janse, Cj" uniqKey="Janse C">CJ Janse</name>
</author>
<author><name sortKey="Cunha Rodrigues, M" uniqKey="Cunha Rodrigues M">M Cunha-Rodrigues</name>
</author>
<author><name sortKey="Ramesar, J" uniqKey="Ramesar J">J Ramesar</name>
</author>
<author><name sortKey="Buscher, P" uniqKey="Buscher P">P Buscher</name>
</author>
<author><name sortKey="Que, I" uniqKey="Que I">I Que</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hansen, Ds" uniqKey="Hansen D">DS Hansen</name>
</author>
<author><name sortKey="Stewart, Cr" uniqKey="Stewart C">CR Stewart</name>
</author>
<author><name sortKey="Jaworowski, A" uniqKey="Jaworowski A">A Jaworowski</name>
</author>
<author><name sortKey="De Koning Ward, Tf" uniqKey="De Koning Ward T">TF de-Koning Ward</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Neill, Al" uniqKey="Neill A">AL Neill</name>
</author>
<author><name sortKey="Chan Ling, T" uniqKey="Chan Ling T">T Chan-Ling</name>
</author>
<author><name sortKey="Hunt, Nh" uniqKey="Hunt N">NH Hunt</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Jennings, Vm" uniqKey="Jennings V">VM Jennings</name>
</author>
<author><name sortKey="Lal, Aa" uniqKey="Lal A">AA Lal</name>
</author>
<author><name sortKey="Hunter, Rl" uniqKey="Hunter R">RL Hunter</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bostrom, S" uniqKey="Bostrom S">S Bostrom</name>
</author>
<author><name sortKey="Giusti, P" uniqKey="Giusti P">P Giusti</name>
</author>
<author><name sortKey="Arama, C" uniqKey="Arama C">C Arama</name>
</author>
<author><name sortKey="Persson, Jo" uniqKey="Persson J">JO Persson</name>
</author>
<author><name sortKey="Dara, V" uniqKey="Dara V">V Dara</name>
</author>
<author><name sortKey="Traore, B" uniqKey="Traore B">B Traore</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Hunt, Nh" uniqKey="Hunt N">NH Hunt</name>
</author>
<author><name sortKey="Grau, Ge" uniqKey="Grau G">GE Grau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Schofield, L" uniqKey="Schofield L">L Schofield</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Dorovini Zis, K" uniqKey="Dorovini Zis K">K Dorovini-Zis</name>
</author>
<author><name sortKey="Schmidt, K" uniqKey="Schmidt K">K Schmidt</name>
</author>
<author><name sortKey="Huynh, H" uniqKey="Huynh H">H Huynh</name>
</author>
<author><name sortKey="Fu, W" uniqKey="Fu W">W Fu</name>
</author>
<author><name sortKey="Whitten, Ro" uniqKey="Whitten R">RO Whitten</name>
</author>
<author><name sortKey="Milner, D" uniqKey="Milner D">D Milner</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Pai, S" uniqKey="Pai S">S Pai</name>
</author>
<author><name sortKey="Qin, J" uniqKey="Qin J">J Qin</name>
</author>
<author><name sortKey="Cavanagh, L" uniqKey="Cavanagh L">L Cavanagh</name>
</author>
<author><name sortKey="Mitchell, A" uniqKey="Mitchell A">A Mitchell</name>
</author>
<author><name sortKey="El Assaad, F" uniqKey="El Assaad F">F El-Assaad</name>
</author>
<author><name sortKey="Jain, R" uniqKey="Jain R">R Jain</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Boivin, Mj" uniqKey="Boivin M">MJ Boivin</name>
</author>
<author><name sortKey="Bangirana, P" uniqKey="Bangirana P">P Bangirana</name>
</author>
<author><name sortKey="Byarugaba, J" uniqKey="Byarugaba J">J Byarugaba</name>
</author>
<author><name sortKey="Opoka, Ro" uniqKey="Opoka R">RO Opoka</name>
</author>
<author><name sortKey="Idro, R" uniqKey="Idro R">R Idro</name>
</author>
<author><name sortKey="Jurek, Am" uniqKey="Jurek A">AM Jurek</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bangirana, P" uniqKey="Bangirana P">P Bangirana</name>
</author>
<author><name sortKey="Allebeck, P" uniqKey="Allebeck P">P Allebeck</name>
</author>
<author><name sortKey="Boivin, Mj" uniqKey="Boivin M">MJ Boivin</name>
</author>
<author><name sortKey="John, Cc" uniqKey="John C">CC John</name>
</author>
<author><name sortKey="Page, C" uniqKey="Page C">C Page</name>
</author>
<author><name sortKey="Ehnvall, A" uniqKey="Ehnvall A">A Ehnvall</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bangirana, P" uniqKey="Bangirana P">P Bangirana</name>
</author>
<author><name sortKey="Opoka, Ro" uniqKey="Opoka R">RO Opoka</name>
</author>
<author><name sortKey="Boivin, Mj" uniqKey="Boivin M">MJ Boivin</name>
</author>
<author><name sortKey="Idro, R" uniqKey="Idro R">R Idro</name>
</author>
<author><name sortKey="Hodges, Js" uniqKey="Hodges J">JS Hodges</name>
</author>
<author><name sortKey="John, Cc" uniqKey="John C">CC John</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ssenkusu, Jm" uniqKey="Ssenkusu J">JM Ssenkusu</name>
</author>
<author><name sortKey="Hodges, Js" uniqKey="Hodges J">JS Hodges</name>
</author>
<author><name sortKey="Opoka, Ro" uniqKey="Opoka R">RO Opoka</name>
</author>
<author><name sortKey="Idro, R" uniqKey="Idro R">R Idro</name>
</author>
<author><name sortKey="Shapiro, E" uniqKey="Shapiro E">E Shapiro</name>
</author>
<author><name sortKey="John, Cc" uniqKey="John C">CC John</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wassmer, Sc" uniqKey="Wassmer S">SC Wassmer</name>
</author>
<author><name sortKey="Taylor, Te" uniqKey="Taylor T">TE Taylor</name>
</author>
<author><name sortKey="Rathod, Pk" uniqKey="Rathod P">PK Rathod</name>
</author>
<author><name sortKey="Mishra, Sk" uniqKey="Mishra S">SK Mishra</name>
</author>
<author><name sortKey="Mohanty, S" uniqKey="Mohanty S">S Mohanty</name>
</author>
<author><name sortKey="Arevalo Herrera, M" uniqKey="Arevalo Herrera M">M Arevalo-Herrera</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cowman, Af" uniqKey="Cowman A">AF Cowman</name>
</author>
<author><name sortKey="Healer, J" uniqKey="Healer J">J Healer</name>
</author>
<author><name sortKey="Marapana, D" uniqKey="Marapana D">D Marapana</name>
</author>
<author><name sortKey="Marsh, K" uniqKey="Marsh K">K Marsh</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cunnington, Aj" uniqKey="Cunnington A">AJ Cunnington</name>
</author>
<author><name sortKey="Walther, M" uniqKey="Walther M">M Walther</name>
</author>
<author><name sortKey="Riley, Em" uniqKey="Riley E">EM Riley</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wassmer, Sc" uniqKey="Wassmer S">SC Wassmer</name>
</author>
<author><name sortKey="Grau, Ge" uniqKey="Grau G">GE Grau</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="De Souza, Jb" uniqKey="De Souza J">JB de Souza</name>
</author>
<author><name sortKey="Hafalla, Jc" uniqKey="Hafalla J">JC Hafalla</name>
</author>
<author><name sortKey="Riley, Em" uniqKey="Riley E">EM Riley</name>
</author>
<author><name sortKey="Couper, Kn" uniqKey="Couper K">KN Couper</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Craig, Ag" uniqKey="Craig A">AG Craig</name>
</author>
<author><name sortKey="Grau, Ge" uniqKey="Grau G">GE Grau</name>
</author>
<author><name sortKey="Janse, C" uniqKey="Janse C">C Janse</name>
</author>
<author><name sortKey="Kazura, Jw" uniqKey="Kazura J">JW Kazura</name>
</author>
<author><name sortKey="Milner, D" uniqKey="Milner D">D Milner</name>
</author>
<author><name sortKey="Barnwell, Jw" uniqKey="Barnwell J">JW Barnwell</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bao, F" uniqKey="Bao F">F Bao</name>
</author>
<author><name sortKey="Shultz, Sr" uniqKey="Shultz S">SR Shultz</name>
</author>
<author><name sortKey="Hepburn, Jd" uniqKey="Hepburn J">JD Hepburn</name>
</author>
<author><name sortKey="Omana, V" uniqKey="Omana V">V Omana</name>
</author>
<author><name sortKey="Weaver, Lc" uniqKey="Weaver L">LC Weaver</name>
</author>
<author><name sortKey="Cain, Dp" uniqKey="Cain D">DP Cain</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shultz, Sr" uniqKey="Shultz S">SR Shultz</name>
</author>
<author><name sortKey="Bao, F" uniqKey="Bao F">F Bao</name>
</author>
<author><name sortKey="Weaver, Lc" uniqKey="Weaver L">LC Weaver</name>
</author>
<author><name sortKey="Cain, Dp" uniqKey="Cain D">DP Cain</name>
</author>
<author><name sortKey="Brown, A" uniqKey="Brown A">A Brown</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Nacer, A" uniqKey="Nacer A">A Nacer</name>
</author>
<author><name sortKey="Movila, A" uniqKey="Movila A">A Movila</name>
</author>
<author><name sortKey="Baer, K" uniqKey="Baer K">K Baer</name>
</author>
<author><name sortKey="Mikolajczak, Sa" uniqKey="Mikolajczak S">SA Mikolajczak</name>
</author>
<author><name sortKey="Kappe, Sh" uniqKey="Kappe S">SH Kappe</name>
</author>
<author><name sortKey="Frevert, U" uniqKey="Frevert U">U Frevert</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Rondina, Mt" uniqKey="Rondina M">MT Rondina</name>
</author>
<author><name sortKey="Weyrich, As" uniqKey="Weyrich A">AS Weyrich</name>
</author>
<author><name sortKey="Zimmerman, Ga" uniqKey="Zimmerman G">GA Zimmerman</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yakubenko, Vp" uniqKey="Yakubenko V">VP Yakubenko</name>
</author>
<author><name sortKey="Yadav, Sp" uniqKey="Yadav S">SP Yadav</name>
</author>
<author><name sortKey="Ugarova, Tp" uniqKey="Ugarova T">TP Ugarova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Yakubenko, Vp" uniqKey="Yakubenko V">VP Yakubenko</name>
</author>
<author><name sortKey="Belevych, N" uniqKey="Belevych N">N Belevych</name>
</author>
<author><name sortKey="Mishchuk, D" uniqKey="Mishchuk D">D Mishchuk</name>
</author>
<author><name sortKey="Schurin, A" uniqKey="Schurin A">A Schurin</name>
</author>
<author><name sortKey="Lam, Sc" uniqKey="Lam S">SC Lam</name>
</author>
<author><name sortKey="Ugarova, Tp" uniqKey="Ugarova T">TP Ugarova</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Van Der Vieren, M" uniqKey="Van Der Vieren M">M Van der Vieren</name>
</author>
<author><name sortKey="Le Trong, H" uniqKey="Le Trong H">H Le Trong</name>
</author>
<author><name sortKey="Wood, Cl" uniqKey="Wood C">CL Wood</name>
</author>
<author><name sortKey="Moore, Pf" uniqKey="Moore P">PF Moore</name>
</author>
<author><name sortKey="St John, T" uniqKey="St John T">T St John</name>
</author>
<author><name sortKey="Staunton, De" uniqKey="Staunton D">DE Staunton</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Wu, H" uniqKey="Wu H">H Wu</name>
</author>
<author><name sortKey="Rodgers, Jr" uniqKey="Rodgers J">JR Rodgers</name>
</author>
<author><name sortKey="Perrard, Xy" uniqKey="Perrard X">XY Perrard</name>
</author>
<author><name sortKey="Perrard, Jl" uniqKey="Perrard J">JL Perrard</name>
</author>
<author><name sortKey="Prince, Je" uniqKey="Prince J">JE Prince</name>
</author>
<author><name sortKey="Abe, Y" uniqKey="Abe Y">Y Abe</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ohayon, A" uniqKey="Ohayon A">A Ohayon</name>
</author>
<author><name sortKey="Golenser, J" uniqKey="Golenser J">J Golenser</name>
</author>
<author><name sortKey="Sinay, R" uniqKey="Sinay R">R Sinay</name>
</author>
<author><name sortKey="Tamir, A" uniqKey="Tamir A">A Tamir</name>
</author>
<author><name sortKey="Altman, A" uniqKey="Altman A">A Altman</name>
</author>
<author><name sortKey="Pollack, Y" uniqKey="Pollack Y">Y Pollack</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
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<li>États-Unis</li>
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<li>État de Rio de Janeiro</li>
</region>
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</settlement>
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<tree><country name="Brésil"><region name="État de Rio de Janeiro"><name sortKey="De Azevedo Quintanilha, Isaclaudia G" sort="De Azevedo Quintanilha, Isaclaudia G" uniqKey="De Azevedo Quintanilha I" first="Isaclaudia G." last="De Azevedo-Quintanilha">Isaclaudia G. De Azevedo-Quintanilha</name>
</region>
<name sortKey="Bozza, Patricia T" sort="Bozza, Patricia T" uniqKey="Bozza P" first="Patrícia T." last="Bozza">Patrícia T. Bozza</name>
<name sortKey="Castro Faria Neto, Hugo C" sort="Castro Faria Neto, Hugo C" uniqKey="Castro Faria Neto H" first="Hugo C." last="Castro-Faria-Neto">Hugo C. Castro-Faria-Neto</name>
<name sortKey="Estato, Vanessa" sort="Estato, Vanessa" uniqKey="Estato V" first="Vanessa" last="Estato">Vanessa Estato</name>
<name sortKey="Ferreira, Andre C" sort="Ferreira, Andre C" uniqKey="Ferreira A" first="André C." last="Ferreira">André C. Ferreira</name>
<name sortKey="Nascimento, Danielle De O" sort="Nascimento, Danielle De O" uniqKey="Nascimento D" first="Danielle De O." last="Nascimento">Danielle De O. Nascimento</name>
<name sortKey="Reis, Patricia A" sort="Reis, Patricia A" uniqKey="Reis P" first="Patricia A." last="Reis">Patricia A. Reis</name>
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</country>
<country name="États-Unis"><region name="Utah"><name sortKey="Campbell, Robert A" sort="Campbell, Robert A" uniqKey="Campbell R" first="Robert A." last="Campbell">Robert A. Campbell</name>
</region>
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<name sortKey="Zimmerman, Guy A" sort="Zimmerman, Guy A" uniqKey="Zimmerman G" first="Guy A." last="Zimmerman">Guy A. Zimmerman</name>
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